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Turbinafine 250mg

FormulationClaim per tabFunction
Ingredient
Mixing:
Turbinafine283 mgAPI
Empress 805 mgSolubliser
Lactose17.0 mgDiluent
Binding
I.P.AQSVehicle
Hpmc e1510 mgBinder
Lubrication
Empress 805.0 mgSolubliser
Mag. Stearate3.5 mgLubricant
Talc4.0 mgLubricant
Aerosil2 mgGlident
Empress U10 mgDissolution improver
Cross povidone10 mgDT improver

Physical properties of tablets

Avg. Weight-350 mg
Hardness-4-5kg/cm2

Procedure

    • Slurry preparation:
      1. Pass accurately weighed Terbinafine ,Empress U, and Lactose through #60 in sifter.
      2. Mix them in a suitable blender for 15 minutes.( Ensure the uniform mixing is the crucial part in acquiring uniform dissolution)
    • Binding and sizing:
      1. Take Iso-Propyl Alcohol &dissolve HPMC E15 bind above mixture properly.
      2. Pass the mass through # 10 sieve or 8mm Perforated screen.
      3. Dry the granules till LOD remains below 2 %.
      4. Again pass through 30# mesh.
    • Lubrication:
      1. Sift the Magnesium Stearate, Empress U, Empress 80,Aerosil, Cross Povidone and Talc through 60# sieve separately.
      2. Mix above mixture in suitable blender.
      3. Compress the tablet having hardness 5-6 kg/cm2.