| Formulation | Claim per tab | Function |
|---|
| Ingredient |
| Mixing: |
| MCCP 101 | 30 mg | Diluent |
| Lactose | QS to 150 mg | Diluent |
| SSG | 10 mg | Disintigerent |
| Aerosil 200 | 1 mg | Glident |
| Binding |
| Glimepiride | 1.05 mg | API |
| MDC | Qs | Vehicle |
| Lubrication |
| Talc | 2mg | Lubricant |
| Mg. Stearate | 2mg | Lubricant |
| Cross Povidone | 3mg | Disintigerent |
| Aerosil 200 | 1 mg | Glident |
| Empress g | 5 mg | Solubliser |
Physical properties of tablets
| Avg. Weight | - | 150 mg |
| Hardness | - | 3-4kg/cm2 |
| Punch size | - | 8mm Standard Concave |
|
*Overage of Glimepiride is taken to compensate the loss
Procedure
- Part I
- Dissolving the vehicle:
- Dissolve Glimepiride in MDC to form a uniform solution, and add it in pre sifted MCCP 101, Lactose and SSG with #60 and dry it till lod >2%
- Lubrication:
- Sift the Magnesium Stearate, Cross Povidone, SSG, EmpressG , Talc through 60# sieve separately, and Aerosil through 40# sieve.
- Mix above mixture in suitable blender.
- Compress the tablet having hardness 3-4 kg/cm2.
Note :
- This is the tentative formulation and the information is based on laboratory work with small scale equipment and does not indicate the product performance.
- Full scale testing and end product performance are the responsibility of the user.
- We suggest that you may be increase or decrease the quantity of polymer and types of Excipients according to your final formulation/requirements.
