Ciprofloxacin 250mg
| Formulation | Claim per tab | Function |
|---|---|---|
| Ingredient | ||
| Mixing: | ||
| Starch | 290 mg | Active Pharmaceutical Ingradient |
| Starch | 18 mg | Filler |
| Lactose | 10.0 mg | Diluent |
| Empress CF | 2.5 mg | Dissolution Improver |
| Aerosil | 2.5 mg | Glident |
| SSG | 5 mg | Disintigerent |
| Binding | ||
| Water | q.s | Vehicle |
| Starch | 3.5 mg | Binder |
| Lubrication | ||
| Empress CF | 5.0 mg | Dissolution improver |
| Mg. Stearate | 3.0 mg | Lubricant |
| Talc | 3.0 mg | Lubricant |
| Cross povidone | 5 mg | DT improver |
| Aerosil | 2.5 mg | Glident |
Physical properties of tablets
| Avg. Weight | - | 350 mg |
| Hardness | - | 5-6 kg/cm2 |
Procedure
- Part I
- Mixing:
- Pass accurately weighed Ciprofloxacin ,EmpressCF,Starch, aerosil, SSG and Lactose through #60 in sifter
- Mix them in a suitable blender for 15 minutes.( Ensure the uniform mixing is the crucial part in acquiring uniform dissolution)
- Binding and sizing:
- Take water & prepare paste using starch slurry andbind above mixture properly.
- Pass the mass through # 10 sieve or 8mm Perforated screen.
- Dry the granules till LOD remains below 2 %.
- Again pass through 20 # mesh.
- Lubrication:
- Sift the Magnesium Stearate, EmpressCF, Cross Povidone and Talc through 60# sieve separately.
- Mix above mixture in suitable blender.
- Compress the tablet having hardness 5-6 kg/cm2.
- Mixing: