Ciprofloxacin 250mg

Physical properties of tablets

Procedure

• Part I
  • Mixing:
    1. Pass accurately weighed Ciprofloxacin ,EmpressCF,Starch, aerosil, SSG and Lactose through #60 in sifter
    2. Mix them in a suitable blender for 15 minutes.( Ensure the uniform mixing is the crucial part in acquiring uniform dissolution)
  • Binding and sizing:
    1. Take water & prepare paste using starch slurry andbind above mixture properly.
    2. Pass the mass through # 10 sieve or 8mm Perforated screen.
    3. Dry the granules till LOD remains below 2 %.
    4. Again pass through 20 # mesh.
  • Lubrication:
    1. Sift the Magnesium Stearate, EmpressCF, Cross Povidone and Talc through 60# sieve separately.
    2. Mix above mixture in suitable blender.
    3. Compress the tablet having hardness 5-6 kg/cm2.