Alfluzocin 10mg
Empress SR
Technically Empress SR is a Carbomer. This grade of carbomer is Benzene Free grade used in oral preparations, in suspensions, tablets, or sustained release preparation. In tablet formulations,
| Formulation | Claim per tab | Function |
|---|---|---|
| Ingredient | ||
| Mixing: | ||
| Alfuzocin | 10mg | Active Pharmaceutical Ingradient |
| Mccp 102 | 65mg | Filler |
| Empress SR | 40.0 mg | Sustained release polymer |
| Mg Stearate | 1 mg | Lubricant |
| Binding | ||
| Talc | 2 mg | Lubricant |
| Aerosil | 1 mg | Glident |
Physical properties of tablets
| Avg. Weight | - | 120 mg |
| Hardness | - | 6-7 kg/cm2 |
Procedure
- Part I
- Mixing:
- Pass alfluzosin and MCCPH102 through 60 # in sifter and mix it in suitable blender for 15 mins.
- Sift the Magnesium Stearate, Talc through 60# sieve separately.
- Mix Empress SR with above mixture in suitable blender.
- Compress the tablet having hardness 6-7 kg/cm2.
- Mixing:
Dissolution study
Apparatus : Paddle [Apparatus-2]
Medium : pH 6.8 Phosphate Buffer
Quantity : 900 ml
RPM : 50
Temp : 37±1oC
| HOURS | 1th | 4th | 8th | 12th |
|---|---|---|---|---|
| % Release | 15% | 47% | 76% | 91% |
| Limit | NMT 20% | 34-61% | 52-82% | NLT 73% |
Note :
- This is the tentative formulation and the information is based on laboratory work with small scale equipment and does not indicate the product performance.
- Full scale testing and end product performance are the responsibility of the user.
- We suggest that you may be increase or decrease the quantity of polymer and types of Excipients according to your final formulation/requirements.